Perio & Hygiene Meta-analysis ✓ Peer reviewed

Efficacy and clinical indications of adjunctive chlorhexidine mouthrinses in nonsurgical and surgical periodontal therapy: A systematic review and meta-analysis.

Periodontology 2000 · Coccoluto L, Antonelli L, Crescenzi I, Crescenzi M, Rotundo R · 2026-09-15

Chlorhexidine mouthrinses as an adjunct to periodontal treatment produced small reductions in pocket depth and bleeding on probing during nonsurgical therapy, but showed no meaningful benefit for attachment loss; in surgical therapy, benefits were limited to early postoperative inflammation control.

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