Periodontitis and Glycaemic Dyscontrol Substantially Increase the Risk of Medication-Related Osteonecrosis of the Jaw: A Preclinical Study in Female Rats.

A preclinical rat study found that combining zoledronate therapy with experimental periodontitis and diabetes significantly increased markers of bone necrosis, inflammation, and osteoclast activity compared to zoledronate alone, suggesting both conditions substantially elevate MRONJ risk.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.