Fluoride & Remin Randomised controlled trial ✓ Peer reviewed

A Randomized Controlled Trial to Evaluate and Compare the Effectiveness of Two Fluoride Varnishes Containing Casein Phosphopeptide-Amorphous Calcium Phosphate and Xylitol with Brushing Twice Daily Regimen in Preventing Dental Caries among 3-6-year-old Preschool Children.

International journal of clinical pediatric dentistry · Salam J, Pandit IK, Gugnani N, Gupta M · 2026-08-01

Two fluoride varnishes—one with xylitol and one with CPP-ACP—both reduced caries progression significantly more than brushing alone in preschool children over 12 months, with no meaningful difference between the varnishes.

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