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Synergistic effects of fish scale-derived nanohydroxyapatite and arginine on enamel surface recovery: a multi-modal in vitro analysis.

Odontology · Thomas NG, Oommen VT, Xavier AM, Das R, Binsi PK, Vellappally S, Naik S, Alfrisany NM, Mani BM, Sunny SM, Schmalz G, Anil S, Chopra A · 2026-09-20

Researchers tested fish scale-derived nanohydroxyapatite combined with arginine alongside fluoride on artificially demineralized human tooth enamel in vitro, finding the three-component combination produced the greatest surface hardness improvement and evidence of enhanced mineral recovery.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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