PAX9 activates autophagy through a transcription-dependent mechanism, promoting EGFR degradation to restrict cell survival in oral cancer.
PAX9 overexpression triggered autophagy and lysosomal activity in oral cancer cells, leading to EGFR breakdown and cell death, while specific PAX9 mutations blocked these effects and allowed cells to survive.
A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.
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Managing the Pregnant Dental Patient
Confident, evidence-based dental care from the first trimester to the postpartum period
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