Perio & Hygiene Review ✓ Peer reviewed

Human Lingual Biofilm Signatures in Gastrointestinal Disease: A Scoping Review.

International dental journal · Fakhruddin KS, Shahwan M, Kamal A, Elmobarik O, Chaiboonyarak T, Nugraha AP, Jung HS, Samaranayake L, Porntaveetus T · 2026-07-28

A review of 25 studies found that tongue biofilm microbial patterns show consistent associations with gastrointestinal disease stages, with shared metabolic signatures across studies. However, current evidence relies on cross-sectional designs without adequate validation, limiting clinical use as diagnostic biomarkers.

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