EFFICACY OF MELATONIN AS AN ADJUNCT TO NONSURGICAL PERIODONTAL THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS.

A systematic review of 18 randomised trials found that melatonin added to nonsurgical periodontal therapy produced modest improvements in clinical attachment level and pocket depth reduction at certain timepoints, though substantial variability between studies and wide prediction intervals suggest benefits may not be consistent across all patient populations.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.