Paediatric & MIH Study ✓ Peer reviewed

Minor salivary gland biopsies in childhood-onset Sjögren's disease show greater inflammation and more frequent fibrotic changes than in adult-onset Sjögren's disease.

Arthritis research & therapy · Riccio F, Ancona S, Lentini VL, Ferro J, Vellone VG, Laffi N, Tirri E, Gattorno M, Rizzo A, Ciccia F, Malattia C, Gandolfo S · 2026-07-22

Children with Sjögren's disease showed greater inflammatory changes and more frequent fibrosis in minor salivary gland biopsies compared to adults, including higher immune cell infiltration and more prominent lymphoid structures despite shorter disease duration.

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