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Sesamin suppresses high glucose-induced cyclooxygenase-2 and prostaglandin E(2) production through Toll-like receptor 2-dependent oxidative stress in human gingival fibroblasts.

Journal of dental sciences · Li YL, Hsu YC, Fan FY, Wang YL, Wu YC, Li SY, Vo TTT, Chang YC, Shih YT, Lee IT · 2026-10-01

Sesamin, a compound from sesame, reduced inflammatory markers and oxidative stress produced by gingival fibroblasts exposed to high glucose levels by suppressing a specific immune signaling pathway involved in diabetes-related periodontal inflammation.

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