Other Research Study ✓ Peer reviewed

p75(NTR) orchestrates chondrogenesis and mechanoadaptation to preserve temporomandibular joint development and homeostasis.

Science advances · Kadota-Watanabe C, Suh J, Yin E, Zhao B, Kim J, Zhang Y, Chang IW, Ramesh S, Lee Y, Chen J, Ahuja M, Jahangiri S, Lao-Ngo I, Eisinger U, Lindsey K, Zhang H, Momen-Heravi F, Du J, Gardner JM, Silva R, Yadav S, Bahney CS, James AW, Kim RH, Klein OD, Hong C · 2026-10-23

Researchers identified p75(NTR) receptor as critical for jaw joint cartilage development and maintenance; its loss impairs cartilage growth and accelerates degeneration, while the BDNF-p75(NTR) signalling pathway promotes cartilage cell survival and function in response to mechanical loading.

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