GZMK⁺CD8⁺ T Cells Induce Acinar Cell Senescence and Salivary Secretion Impairment in Sjögren's Syndrome via Mitochondrial Dysfunction and TMEM16A Chloride Channel Disruption.
Researchers found that specific immune cells (GZMK⁺CD8⁺ T cells) damage salivary gland cells in Sjögren's syndrome by causing ageing and dysfunction through oxidative stress, mitochondrial damage, and disruption of chloride channels required for saliva production.
A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.
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