Other Research Study ✓ Peer reviewed

Significantly higher frequencies of anemia, vitamin B12 deficiency, and hyperhomocysteinemia in recurrent aphthous stomatitis patients with macrocytosis.

Journal of dental sciences · Wu YH, Wang YP, Lee YP, Chang JY, Sun A, Chiang CP · 2026-10-01

Researchers compared blood markers in recurrent aphthous stomatitis patients with enlarged red blood cells to healthy controls and RAS patients without this condition. Those with enlarged red blood cells showed significantly higher rates of anemia, vitamin B12 deficiency, and elevated homocysteine levels.

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