Perio & Hygiene Study ✓ Peer reviewed

Periodontitis and Neuropsychiatric Disorders: Epidemiological and Mechanistic Evidence.

Journal of periodontal research · Ríos-Barbero J, Martínez M, Ambrosio N, García-Bueno B, Fraguas D, Leza JC, Sanz M, Figuero E · 2026-09-04

This review examined evidence linking periodontitis to neuropsychiatric disorders, finding the strongest associations with depression and anxiety. Proposed mechanisms include microbial translocation, systemic inflammation, and shared risk factors, though most evidence remains cross-sectional and causality remains unclear.

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