Airways & Growth Systematic review ✓ Peer reviewed

Molecular effects of areca nut-derived compounds on human oral cancer cells: a systematic review of in vitro evidence.

Journal of oral biology and craniofacial research · Ayna VKP, Tampubolon IA, Widowati K, Sarasati A, Ayuningtyas NF, Surboyo MDC · 2026-07-01

Researchers systematically reviewed 20 laboratory studies examining how areca nut compounds affect human oral cancer cells, finding that these compounds triggered inflammation, increased cell growth, elevated oxidative stress, and altered cancer-related signalling pathways.

A plain-English summary of the study's own findings — we don't add our own claims or interpretation. Read the full paper for the complete methods and results, and apply your own clinical judgement.

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